Natural hormone replacement therapy is simply using plant-derived hormones, which match the ovary’s own estrogen and progesterone, as the replacement choice. These hormones are produced by major pharmaceutical corporations under the same exacting conditions as all other prescription drugs. The central benefit of natural hormones appears to be less side effects. Specifically, breast tenderness, bloating and weight gain appear to decrease on natural estrogen. Mood swings and irritability seem to be less on natural progesterone. Renaissance physicians can answer important questions about hormone replacement therapy.